Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet

Hannu Mykka¨nen1  https://168pg.net/
, Pirkka V. Kirjavainen1,four
1. Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, Food and Health Research
Centre, University of Eastern Finland, Kuopio, Finland, 2. Institute of Biomedicine, University of Eastern
Finland, Kuopio, Finland, 3. Institute of Biomedicine and Biocenter of Oulu, University of Oulu, Medical Center
Oulu and Oulu University Hospital, Oulu, Finland, four. Department of Environmental Health, National Institute
for Health and Welfare, Kuopio, Finland
*otto.Mykkanen@uef.Fi
Abstract
Background: Low-grade metabolic infection and hypertension are primary
mechanisms concerned in obesity-related adverse health outcomes. Berries,
in particular Nordic wild blueberries (hereafter known as bilberries), constitute an
crucial supply of nutritional anthocyanins, a collection of polyphenols with ability
beneficial outcomes to fight obesity-related metabolic disturbances.
Methods: The effects of 5% or 10% (w/w) of whole bilberries (BB) had been studied on
the improvement of weight problems and its metabolic disturbances in C57BL mice fed with a
high-fats weight loss plan (HFD) for 3 months. Cytokines, inflammatory cells, systolic blood
stress, glucose tolerance, insulin sensitivity, weight advantage, body fats, food
intake and energy metabolism were assessed.
Results: Bilberries ameliorated type 1 pro-inflammatory responsiveness precipitated
by means of HFD. This changed into indicated via the altered cytokine profile and the reduced
incidence of interferon gamma -generating T-cells, in particular T helper kind 1
cells. Bilberries additionally avoided the progression of weight problems related long time
boom in systolic blood stress in mice.
Conclusions: Bilberries reduce the development of systemic irritation and
save you the development of continual hypertension, hence supporting their ability function
in assuaging the detrimental health consequences related to developing obesity.
OPEN ACCESS
Citation: Mykka¨nen OT, Huotari A, Herzig K-H,
Dunlop TW, Mykka¨nen H, et al. (2014) Wild
Blueberries (Vaccinium myrtillus) Alleviate
Inflammation and Hypertension Associated with
Developing Obesity in Mice Fed with a High-Fat
Diet. PLoS ONE nine(12): e114790. Doi:10.1371/
magazine.Pone.0114790
Editor: Michael Mu¨ller, University of East Anglia,
United Kingdom
Received: April 7, 2014
Accepted: November three, 2014
Published: December 12, 2014
Copyright: 2014 Mykka¨nen et al. This is an
open-access article distributed below the phrases of
the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, supplied the unique author
and supply are credited.
Data Availability: The authors affirm that each one facts
underlying the findings are completely available without
limit. All data underlying the findings presented on this paper, and essential to duplicate the
outcomes, are freely to be had within the paper and its
Supporting Information files. The larger dataset,
which includes extra statistics, is to be had
upon request, because it contains 0.33 birthday party records and is
very big. Requests may be sent to the
corresponding writer.
Funding: The work become supported with the aid of the
Academy of Finland assignment #133431 (Effects of
berry intake on weight problems-associated metabolic
problems) (http://www.Aka.Fi/), the Graduate School
of Applied Biosciences (http://www.Vetmed.Helsinki.
Fi/abs/), Yrjo¨ Jahnsson Foundation (http://www.Yjs.
Fi/), The Northern Savo Fund of Finnish Cultural
Foundation (https://www.Skr.Fi/), Olvi Foundation
(http://www.Olvisaatio.Fi/), the University of Eastern
Finland (http://www.Uef.Fi/) and in element through grants
from the Academy of Finland (#108478 and
#129568). Bilberries had been kindly provided as present
from a nearby corporation, Joswola, Iisalmi, Finland
and freeze dried inside European networks mission
collaboration (ELLU). The funders had no function in
observe design, records series and evaluation, choice
to put up, or guidance of the manuscript.
Competing Interests: Bilberries had been kindly
furnished as a gift from Joswola, Iisalmi, Finland.
This does not modify the authors’ adherence to all
the PLOS ONE regulations on sharing statistics and
substances, as unique online inside the guide for

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